antibiotics mode of action and mechanisms of resistance pdf

Antibiotics Mode Of Action And Mechanisms Of Resistance Pdf

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Antibiotics by Mechanism of Action

Author s : Nicole J. Johnston , Tariq A. Mukhtar , Gerard D. DOI : The streptogramin antibiotics were discovered over 40 years ago but are only now emerging as important therapeutic agents for the treatment of infection caused by a variety of bacteria. The streptogramins consist of mixtures of two structurally distinct compounds, type A and type B, which are separately bacteriostatic, but bactericidal in appropriate ratios.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Review Free to read. Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide. Multidrug-resistant organisms have emerged not only in the hospital environment but are now often identified in community settings, suggesting that reservoirs of antibiotic-resistant bacteria are present outside the hospital. Therefore, understanding the biochemical and genetic basis of resistance is of paramount importance to design strategies to curtail the emergence and spread of resistance and devise innovative therapeutic approaches against multidrug-resistant organisms.

Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance

Reviewed: February 14th Published: February 27th Pathogenic microorganisms can infect tissues of human by destroying cellular functions. Microorganisms themselves or their toxins can damage host cells. Microbial infections are treated with antimicrobials by either inhibiting the microbial growth or killing the microorganism. Antibiotics are widely being used not only in the treatment of acute and chronic infections, but also in the prophylactic treatment [ 1 ].

Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance

History of mankind is regarded as struggle against infectious diseases. Rather than observing the withering away of bacterial diseases, antibiotic resistance has emerged as a serious global health concern. Medium of antibiotic resistance in bacteria varies greatly and comprises of target protection, target substitution, antibiotic detoxification and block of intracellular antibiotic accumulation.

Antimicrobial resistance AMR or AR occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials. These approaches may also be more expensive. Microbes resistant to multiple antimicrobials are called multidrug resistant MDR.

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Infections account for a major cause of death throughout the developing world.


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