structure and function of long noncoding rnas in epigenetic regulation pdf

Structure And Function Of Long Noncoding Rnas In Epigenetic Regulation Pdf

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Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma HCC , the major adult liver malignancy. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development.

Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts that includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity. Here, we highlight recent efforts that have identified a myriad of molecular functions for long noncoding RNAs.

Epigenetics is the study of inherited changes in phenotype appearance or gene expression that are caused by mechanisms other than changes in the underlying DNA sequence 1 , 2. These changes may persist through multiple cell divisions, even for the remainder of the cell's life, and may also last for multiple generations. However, to reiterate, there is no change in the underlying DNA sequence of the organism.

Long noncoding RNAs: functional surprises from the RNA world

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Genomes of complex organisms encode an abundance and diversity of long noncoding RNAs lncRNAs that are expressed throughout the cell and fulfill a wide variety of regulatory roles at almost every stage of gene expression. These roles, which encompass sensory, guiding, scaffolding and allosteric capacities, derive from folded modular domains in lncRNAs.

Epigenetic regulation of long non-coding RNAs in gastric cancer

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial , Introducing OncoTarget. Sponsored Conferences.

Long Non-coding RNA Structure and Function: Is There a Link?

Recently, the non-coding RNAs ncRNAs have been classified in different categories, and its importance in regulating different cellular processes has been unravelled. Some lncRNAs are related to genomic imprinting and are associated with chromatin-modifying complexes that can regulate gene transcription. It is well established that cancer cells have different epigenetic alterations and some of these modifications are associated with lncRNAs. Studies of cancer-associated lncRNAs have defined its function in the process of tumorigenesis, its impact on cell proliferation, cellular signalling, angiogenesis and metastasis. Therefore, having a better knowledge of their role might contribute to a better understanding of the diseases.

Structure and function of long noncoding RNAs in epigenetic regulation

Epigenetic regulation of long non-coding RNAs in gastric cancer

The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. LncRNAs now have been shown to play important epigenetic regulatory roles in key molecular processes, such as gene expression, genetic imprinting, histone modification, chromatin dynamics, and other activities by forming specific structures and interacting with all kinds of molecules. This paper mainly discusses the correlation between the structure and function of lncRNAs with the recent progress in epigenetic regulation, which is important to the understanding of the mechanism of lncRNAs in physiological and pathological processes. Recently, the rapid development and application of high-throughput sequencing technology further steadies the key situation of the connecting link of RNA in the focal dogma [ 1 , 2 ]. Through genome-wide human transcriptional studies, more and more new non-coding RNAs have been found [ 3 ].

RNA has emerged as the prime target for diagnostics, therapeutics and the development of personalized medicine. Thus, ncRNAs confer regulatory plasticity and represent a new layer of epigenetic control that is dysregulated in disease. LncRNAs tend to acquire complex secondary and tertiary structures and their functions only impose very subtle sequence constraints. In the present review we will discuss the biochemical assays that can be employed to determine the lncRNA structural configurations. The implications and challenges of linking function and lncRNA structure to design novel RNA therapeutic approaches will also be analyzed.

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PDF | Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than nucleotides. The post-transcriptional regulation is.


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Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs


Rafael H.

Long noncoding RNAs (lncRNAs) fulfill a variety of regulatory roles in gene expression, which are dictated by their RNA structure, chemistry.



Request PDF | Structure and function of long noncoding RNAs in epigenetic regulation | Genomes of complex organisms encode an.


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